TY - JOUR
T1 - Cloning and characterization of the 5'-flanking region of the human cardiotrophin-1 gene
AU - Erdmann, Jeanette
AU - Hassfeld, Sabine
AU - Kallisch, Heike
AU - Fleck, Eckart
AU - Regitz-Zagrosek, Vera
PY - 1998/3/17
Y1 - 1998/3/17
N2 - To enable the analysis of the regulation of the human cardiotrophin-1 gene expression, the 5'-flanking region of the human cardiotrophin-1 gene was cloned and sequenced. Data bank search revealed several cis-active DNA elements (SP1, CREB, C/EBP, AP1 and AP2 like and GATA) in the proximal 1.1 kb region. Six nested 5-'terminal deletion mutants from -1091/+39 to -218/+39 were fused to a luciferase reportergene and proved to be functionally active after transfection into COS-7 cells.
AB - To enable the analysis of the regulation of the human cardiotrophin-1 gene expression, the 5'-flanking region of the human cardiotrophin-1 gene was cloned and sequenced. Data bank search revealed several cis-active DNA elements (SP1, CREB, C/EBP, AP1 and AP2 like and GATA) in the proximal 1.1 kb region. Six nested 5-'terminal deletion mutants from -1091/+39 to -218/+39 were fused to a luciferase reportergene and proved to be functionally active after transfection into COS-7 cells.
UR - http://www.scopus.com/inward/record.url?scp=0032539769&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1998.8311
DO - 10.1006/bbrc.1998.8311
M3 - Journal articles
C2 - 9514957
AN - SCOPUS:0032539769
SN - 0006-291X
VL - 244
SP - 494
EP - 497
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
