Clinico-pathologic function of cerebral ABC transporters - Implications for the pathogenesis of Alzheimer's disease

Jens Pahnke*, Olaf Wolkenhauer, Markus Krohn, Lary C. Walker

*Corresponding author for this work
28 Citations (Scopus)

Abstract

In recent years it has become evident that ABC transporters fulfill important barrier functions in normal organs and during disease processes. Most importantly, resistance to drugs in cancer cells led to intense oncological and pharmacological investigations in which researchers were able to highlight important pharmacological interactions of chemotherapeuticals with ABC transporter function. Recently, the development of neurodegenerative diseases and the maintenance of neuronal stem cells have been linked to the activity of ABC transporters. Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer's disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment.

Original languageEnglish
JournalCurrent Alzheimer research
Volume5
Issue number4
Pages (from-to)396-405
Number of pages10
ISSN1567-2050
DOIs
Publication statusPublished - 08.2008

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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