TY - JOUR
T1 - Clinical factors asssociated with treatment outcomes following whole-brain irradiation in patients with prostate cancer
AU - Dziggel, Liesa
AU - Schild, Steven E.
AU - Veninga, Theo
AU - Bajrovic, Amira
AU - Rades, Dirk
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Background/Aim: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. Patients and Methods: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursivepartitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival. Results: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival. Conclusion: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.
AB - Background/Aim: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. Patients and Methods: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursivepartitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival. Results: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival. Conclusion: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=85015813697&partnerID=8YFLogxK
U2 - 10.21873/invivo.11021
DO - 10.21873/invivo.11021
M3 - Journal articles
C2 - 28064217
AN - SCOPUS:85015813697
SN - 0258-851X
VL - 31
SP - 35
EP - 38
JO - In Vivo
JF - In Vivo
IS - 1
ER -
