Clinical factors asssociated with treatment outcomes following whole-brain irradiation in patients with prostate cancer

Liesa Dziggel, Steven E. Schild, Theo Veninga, Amira Bajrovic, Dirk Rades*

*Corresponding author for this work
    9 Citations (Scopus)

    Abstract

    Background/Aim: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. Patients and Methods: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursivepartitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival. Results: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival. Conclusion: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.

    Original languageEnglish
    JournalIn Vivo
    Volume31
    Issue number1
    Pages (from-to)35-38
    Number of pages4
    ISSN0258-851X
    DOIs
    Publication statusPublished - 2017

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