Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Klaus Peter Wandinger; Peter Trillenberg; Harald Klüter; Karl Wessel; Holger Kirchner

doi:10.1016/S0967-5868(99)90027-9

Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Klaus Peter Wandinger^*, Peter Trillenberg, Harald Klüter, Karl Wessel, Holger Kirchner

^*Corresponding author for this work

6 Citations (Scopus)

Abstract

The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

Original language	English
Journal	Journal of Clinical Neuroscience
Volume	6
Issue number	5
Pages (from-to)	373-374
Number of pages	2
ISSN	0967-5868
DOIs	https://doi.org/10.1016/S0967-5868(99)90027-9
Publication status	Published - 01.01.1999

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/S0967-5868(99)90027-9

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abstract = "The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.",

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AU - Wandinger, Klaus Peter

AU - Trillenberg, Peter

AU - Klüter, Harald

AU - Wessel, Karl

AU - Kirchner, Holger

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

AB - The clinical and molecular findings in three patients with multiple sclerosis (MS) and additional type 1 diabetes mellitus are described. These patients all presented with a severe and progressive disease course of MS. Molecular testing for HLA class II genes demonstrated the presence of the haplotype DRB1*0401, DQB1*0302 in all patients. This haplotype is closely linked to type 1 diabetes mellitus and is increased among patients with the primary progressive subtype of MS. We conclude that the immunogenetic background in patients with diabetes mellitus may determine the seventy and clinical course of MS in these individuals.

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JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

IS - 5

ER -

Clinical and molecular findings in multiple sclerosis patients with type 1 diabetes mellitus

Abstract

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