Claudin-1 expression in cervical cancer

Friederike Hoellen, Annika Waldmann, Constanze Banz-Jansen, Uwe Holtrich, Thomas Karn, Martina Oberländer, Jens K Habermann, Mareike Hörmann, Frank Köster, Julika Ribbat-Idel, Marc Thill, Achim Rody, Ahmed El-Balat, Lars Hanker

Abstract

Claudin-1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin-1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin-1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin-1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin-1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin-1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin-1-negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin-1-negative patients. In order to elucidate whether claudin-1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required.
Original languageEnglish
JournalMol Clin Oncol
Volume7
Issue number5
Pages (from-to)880-884
Number of pages5
ISSN2049-9450
DOIs
Publication statusPublished - 01.11.2017

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Research Area: Center for Population Medicine and Public Health (ZBV)

Fingerprint

Dive into the research topics of 'Claudin-1 expression in cervical cancer'. Together they form a unique fingerprint.

Cite this