Abstract
Claudin-1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin-1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin-1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin-1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin-1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin-1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin-1-negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin-1-negative patients. In order to elucidate whether claudin-1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required.
Original language | English |
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Journal | Mol Clin Oncol |
Volume | 7 |
Issue number | 5 |
Pages (from-to) | 880-884 |
Number of pages | 5 |
ISSN | 2049-9450 |
DOIs | |
Publication status | Published - 01.11.2017 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
- Research Area: Center for Population Medicine and Public Health (ZBV)