Circulating tumor cells in breast cancer-current status and perspectives

Malgorzata Banys-Paluchowski*, Natalia Krawczyk, Franziska Meier-Stiegen, Tanja Fehm

*Corresponding author for this work
    25 Citations (Scopus)


    The phenomenon of tumor cell dissemination through the blood stream has been known since the 19th century. Circulating tumor cells (CTCs) may be detected in peripheral blood of patients with breast cancer and may serve as a surrogate marker for minimal residual disease. Prognostic relevance of CTCs has already been demonstrated in early and metastatic breast cancer and commercially available detection systems are currently employed in various clinical trials. Since peripheral blood is an easily accessible compartment, serial reevaluation of CTCs is possible and may contribute to better therapy monitoring. Another potential of CTCs lies in the characterization of tumor cells. Expression profiles may differ between CTCs and primary tumor, which may result in different responses to treatment. Assessment of molecular features of CTCs may be an important step for the optimization of adjuvant and metastatic systemic therapy.

    Original languageEnglish
    JournalCritical Reviews in Oncology/Hematology
    Pages (from-to)22-29
    Number of pages8
    Publication statusPublished - 01.01.2016


    Dive into the research topics of 'Circulating tumor cells in breast cancer-current status and perspectives'. Together they form a unique fingerprint.

    Cite this