Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Rana Ezzeddini; Masoud Darabi; Babollah Ghasemi; Yalda Jabbari; Shahin Abdollahi; Nadereh Rashtchizadeh; Abasaad Gharahdaghi; Maryam Darabi; Masoud Ansarin; Maghsood Shaaker; Akbar Samadi; Jamal Karamravan

doi:10.1016/j.ijporl.2011.12.026

Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Rana Ezzeddini, Masoud Darabi^*, Babollah Ghasemi, Yalda Jabbari, Shahin Abdollahi, Nadereh Rashtchizadeh, Abasaad Gharahdaghi, Maryam Darabi^*, Masoud Ansarin, Maghsood Shaaker, Akbar Samadi, Jamal Karamravan

^*Corresponding author for this work

Clinic of Hematology and Oncology

9 Citations (Scopus)

Abstract

Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.

Original language	English
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	76
Issue number	4
Pages (from-to)	471-474
Number of pages	4
ISSN	0165-5876
DOIs	https://doi.org/10.1016/j.ijporl.2011.12.026
Publication status	Published - 04.2012

Funding

The research was supported by a grant to M.D. (89-21 from the Tuberculosis and Lung Research Center of Tabriz University of Medical Sciences ). This study was conducted as a Master's thesis project no. 90/7 at the Tabriz University of Medical Sciences for the R.E. under the supervision of M.D.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ijporl.2011.12.026

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Ezzeddini, R., Darabi, M., Ghasemi, B., Jabbari, Y., Abdollahi, S., Rashtchizadeh, N., Gharahdaghi, A., Darabi, M., Ansarin, M., Shaaker, M., Samadi, A., & Karamravan, J. (2012). Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis. International Journal of Pediatric Otorhinolaryngology, 76(4), 471-474. https://doi.org/10.1016/j.ijporl.2011.12.026

@article{6d0949256b654b4ab89ebb20dab9c8be,

title = "Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis",

abstract = "Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.",

author = "Rana Ezzeddini and Masoud Darabi and Babollah Ghasemi and Yalda Jabbari and Shahin Abdollahi and Nadereh Rashtchizadeh and Abasaad Gharahdaghi and Maryam Darabi and Masoud Ansarin and Maghsood Shaaker and Akbar Samadi and Jamal Karamravan",

note = "Funding Information: The research was supported by a grant to M.D. (89-21 from the Tuberculosis and Lung Research Center of Tabriz University of Medical Sciences ). This study was conducted as a Master's thesis project no. 90/7 at the Tabriz University of Medical Sciences for the R.E. under the supervision of M.D.",

year = "2012",

month = apr,

doi = "10.1016/j.ijporl.2011.12.026",

language = "English",

volume = "76",

pages = "471--474",

journal = "International Journal of Pediatric Otorhinolaryngology",

issn = "0165-5876",

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number = "4",

}

Ezzeddini, R, Darabi, M, Ghasemi, B, Jabbari, Y, Abdollahi, S, Rashtchizadeh, N, Gharahdaghi, A, Darabi, M, Ansarin, M, Shaaker, M, Samadi, A & Karamravan, J 2012, 'Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis', International Journal of Pediatric Otorhinolaryngology, vol. 76, no. 4, pp. 471-474. https://doi.org/10.1016/j.ijporl.2011.12.026

TY - JOUR

T1 - Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

AU - Ezzeddini, Rana

AU - Darabi, Masoud

AU - Ghasemi, Babollah

AU - Jabbari, Yalda

AU - Abdollahi, Shahin

AU - Rashtchizadeh, Nadereh

AU - Gharahdaghi, Abasaad

AU - Darabi, Maryam

AU - Ansarin, Masoud

AU - Shaaker, Maghsood

AU - Samadi, Akbar

AU - Karamravan, Jamal

N1 - Funding Information: The research was supported by a grant to M.D. (89-21 from the Tuberculosis and Lung Research Center of Tabriz University of Medical Sciences ). This study was conducted as a Master's thesis project no. 90/7 at the Tabriz University of Medical Sciences for the R.E. under the supervision of M.D.

PY - 2012/4

Y1 - 2012/4

N2 - Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.

AB - Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.

UR - https://www.scopus.com/pages/publications/84859006665

U2 - 10.1016/j.ijporl.2011.12.026

DO - 10.1016/j.ijporl.2011.12.026

M3 - Journal articles

C2 - 22297210

AN - SCOPUS:84859006665

SN - 0165-5876

VL - 76

SP - 471

EP - 474

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

IS - 4

ER -

Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Abstract

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UN SDGs

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