TY - JOUR
T1 - Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis
AU - Ezzeddini, Rana
AU - Darabi, Masoud
AU - Ghasemi, Babollah
AU - Jabbari, Yalda
AU - Abdollahi, Shahin
AU - Rashtchizadeh, Nadereh
AU - Gharahdaghi, Abasaad
AU - Darabi, Maryam
AU - Ansarin, Masoud
AU - Shaaker, Maghsood
AU - Samadi, Akbar
AU - Karamravan, Jamal
N1 - Funding Information:
The research was supported by a grant to M.D. (89-21 from the Tuberculosis and Lung Research Center of Tabriz University of Medical Sciences ). This study was conducted as a Master's thesis project no. 90/7 at the Tabriz University of Medical Sciences for the R.E. under the supervision of M.D.
PY - 2012/4
Y1 - 2012/4
N2 - Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.
AB - Objective: Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. Methods: Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results: The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P< 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r= 0.26; P= 0.02), which was not apparent in OSA (r= 0.14; P= 0.09). Conclusion: This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.
UR - http://www.scopus.com/inward/record.url?scp=84859006665&partnerID=8YFLogxK
U2 - 10.1016/j.ijporl.2011.12.026
DO - 10.1016/j.ijporl.2011.12.026
M3 - Journal articles
C2 - 22297210
AN - SCOPUS:84859006665
SN - 0165-5876
VL - 76
SP - 471
EP - 474
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
IS - 4
ER -
