Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa

Wolfgang Schreiber; Ulrich Schweiger; Detlev Werner; Gerhard Brunner; Reinhard J. Tuschl; Reinhold G. Laessle; Jürgen Christian Krieg; Manfred M. Fichter; Karl Martin Pirke

doi:10.1016/0026-0495(91)90231-K

Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa

Wolfgang Schreiber^*, Ulrich Schweiger, Detlev Werner, Gerhard Brunner, Reinhard J. Tuschl, Reinhold G. Laessle, Jürgen Christian Krieg, Manfred M. Fichter, Karl Martin Pirke

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

Max Planck Institute

28 Citations (Scopus)

Abstract

Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T₃) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function.

Original language	English
Journal	Metabolism
Volume	40
Issue number	5
Pages (from-to)	503-507
Number of pages	5
ISSN	0026-0495
DOIs	https://doi.org/10.1016/0026-0495(91)90231-K
Publication status	Published - 05.1991

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa",

abstract = "Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T3) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function.",

author = "Wolfgang Schreiber and Ulrich Schweiger and Detlev Werner and Gerhard Brunner and Tuschl, {Reinhard J.} and Laessle, {Reinhold G.} and Krieg, {J{\"u}rgen Christian} and Fichter, {Manfred M.} and Pirke, {Karl Martin}",

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doi = "10.1016/0026-0495(91)90231-K",

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T1 - Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa

AU - Schreiber, Wolfgang

AU - Schweiger, Ulrich

AU - Werner, Detlev

AU - Brunner, Gerhard

AU - Tuschl, Reinhard J.

AU - Laessle, Reinhold G.

AU - Krieg, Jürgen Christian

AU - Fichter, Manfred M.

AU - Pirke, Karl Martin

PY - 1991/5

Y1 - 1991/5

N2 - Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T3) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function.

AB - Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T3) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function.

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SN - 0026-0495

VL - 40

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EP - 507

JO - Metabolism

JF - Metabolism

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ER -

Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa

Abstract

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UN SDGs

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