Circadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain

Dominic Landgraf; Anne Marie Neumann; Henrik Oster

doi:10.1016/j.beem.2017.10.007

Circadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain

Dominic Landgraf, Anne Marie Neumann, Henrik Oster^*

^*Corresponding author for this work

20 Citations (Scopus)

Abstract

Food intake and sleep are two mutually exclusive behaviors and both are normally confined to opposing phases of the diurnal cycle. The temporal coordination of behavior and physiology along the 24-h day–night cycle is organized by a network of circadian clocks that orchestrate transcriptional programs controlling cellular physiology. Many of the peptide hormones of the gastrointestinal tract are not only secreted in a circadian fashion, they can also affect circadian clock function in peripheral metabolic tissues and the brain, thus providing metabolic feedback to metabolic and neurobehavioral circuits. In this review, we summarize the current knowledge on this gastrointestinal peptide crosstalk and its potential role in the coordination of nutrition and the maintenance of metabolic homeostasis.

Original language	English
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	31
Issue number	6
Pages (from-to)	561-571
Number of pages	11
ISSN	1521-690X
DOIs	https://doi.org/10.1016/j.beem.2017.10.007
Publication status	Published - 01.12.2017

Funding

This work was supported grants of the German Research Foundation (SFB-134 & GRK-1957 (HO, AMN) & Emmy Noehter Program (DL)) and the Volkswagen Foundation (Lichtenberg Program (HO)). We thank Dr. Rita Barandas for critical comments on the manuscript.

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.22-17 Endocrinology, Diabetology, Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.beem.2017.10.007

Cite this

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title = "Circadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain",

abstract = "Food intake and sleep are two mutually exclusive behaviors and both are normally confined to opposing phases of the diurnal cycle. The temporal coordination of behavior and physiology along the 24-h day–night cycle is organized by a network of circadian clocks that orchestrate transcriptional programs controlling cellular physiology. Many of the peptide hormones of the gastrointestinal tract are not only secreted in a circadian fashion, they can also affect circadian clock function in peripheral metabolic tissues and the brain, thus providing metabolic feedback to metabolic and neurobehavioral circuits. In this review, we summarize the current knowledge on this gastrointestinal peptide crosstalk and its potential role in the coordination of nutrition and the maintenance of metabolic homeostasis.",

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AU - Landgraf, Dominic

AU - Neumann, Anne Marie

AU - Oster, Henrik

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N2 - Food intake and sleep are two mutually exclusive behaviors and both are normally confined to opposing phases of the diurnal cycle. The temporal coordination of behavior and physiology along the 24-h day–night cycle is organized by a network of circadian clocks that orchestrate transcriptional programs controlling cellular physiology. Many of the peptide hormones of the gastrointestinal tract are not only secreted in a circadian fashion, they can also affect circadian clock function in peripheral metabolic tissues and the brain, thus providing metabolic feedback to metabolic and neurobehavioral circuits. In this review, we summarize the current knowledge on this gastrointestinal peptide crosstalk and its potential role in the coordination of nutrition and the maintenance of metabolic homeostasis.

AB - Food intake and sleep are two mutually exclusive behaviors and both are normally confined to opposing phases of the diurnal cycle. The temporal coordination of behavior and physiology along the 24-h day–night cycle is organized by a network of circadian clocks that orchestrate transcriptional programs controlling cellular physiology. Many of the peptide hormones of the gastrointestinal tract are not only secreted in a circadian fashion, they can also affect circadian clock function in peripheral metabolic tissues and the brain, thus providing metabolic feedback to metabolic and neurobehavioral circuits. In this review, we summarize the current knowledge on this gastrointestinal peptide crosstalk and its potential role in the coordination of nutrition and the maintenance of metabolic homeostasis.

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DO - 10.1016/j.beem.2017.10.007

M3 - Scientific review articles

C2 - 29224668

AN - SCOPUS:85033233450

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JO - Best Practice and Research: Clinical Endocrinology and Metabolism

JF - Best Practice and Research: Clinical Endocrinology and Metabolism

IS - 6

ER -

Circadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

RTG 1957: Adipocyte-Brain Crosstalk

Cite this

Circadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

RTG 1957: Adipocyte-Brain Crosstalk

Cite this