Ciliary neurotrophic factor influences endocrine adipocyte function: Inhibition of leptin via PI 3-kinase

Volker Ott, Mathias Fasshauer, Britta Meier, Andreas Dalski, Daniel Kraus, Thomas W. Gettys, Nina Perwitz, Johannes Klein

20 Citations (Scopus)

Abstract

Ciliary neurotrophic factor (CNTF), originally known for its involvement in the modulation of neuronal growth, has been discovered to exert anorexigenic effects and is currently being investigated in clinical studies for the treatment of obesity and insulin resistance. This neuropeptide acts on the central nervous system. However, we have recently demonstrated direct peripheral effects on adipocyte signalling and thermogenesis. Given the emerging endocrine role of adipose tissue in the regulation of energy homeostasis and insulin resistance, we investigated potential effects of CNTF on leptin expression and secretion. Our study demonstrates a direct inhibition of leptin expression and secretion by acute and chronic CNTF treatment. Furthermore, we demonstrate a differentiation- and Janus kinase 2 (JAK2)-independent, but phosphatidylinositol 3-kinase-dependent signalling pathway mediating this negative effect. These results provide novel evidence for a role of CNTF in the selective modulation of adipocyte endocrine function which may have important implications for the regulation of energy homeostasis.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume224
Issue number1-2
Pages (from-to)21-27
Number of pages7
ISSN0303-7207
DOIs
Publication statusPublished - 30.09.2004

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