Chronobiology, sleep-related risk factors and light therapy in perinatal depression: The "Life-ON" project

Simone Baiardi; Fabio Cirignotta; Alessandro Cicolin; Corrado Garbazza; Armando D'Agostino; Orsola Gambini; Alessandra Giordano; Mariapaola Canevini; Elena Zambrelli; Anna Maria Marconi; Susanna Mondini; Stefan Borgwardt; Christian Cajochen; Nicola Rizzo; Mauro Manconi

doi:10.1186/s12888-016-1086-0

Chronobiology, sleep-related risk factors and light therapy in perinatal depression: The "Life-ON" project

Simone Baiardi, Fabio Cirignotta, Alessandro Cicolin, Corrado Garbazza, Armando D'Agostino, Orsola Gambini, Alessandra Giordano, Mariapaola Canevini, Elena Zambrelli, Anna Maria Marconi, Susanna Mondini, Stefan Borgwardt, Christian Cajochen, Nicola Rizzo, Mauro Manconi^*

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

23 Citations (Scopus)

Abstract

Background: Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship. Bright light therapy (BLT) is a well-tested and safe treatment, effective in both depression and circadian/sleep disorders. Methods: In a 3-year longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery. The primary aim of the present study is to systematically explore and characterize risk factors for PND by prospective sleep assessment (using wrist actigraphy, polysomnography and various sleep questionnaires) and bloodbased analysis of potential markers during the perinatal period (Life-ON study). Secondary aims are to explore the relationship between specific genetic polymorphisms and PND (substudy Life-ON1), to investigate the effectiveness of BLT in treating PND (substudy Life-ON2) and to test whether a short term trial of BLT during pregnancy can prevent PND (substudy Life-ON3). Discussion: The characterization of specific predictive and risk factors for PND may substantially contribute to improve preventive medical and social strategies for the affected women. The study results are expected to promote a better understanding of the relationship between sleep disorders and the development of PND and to confirm, in a large sample of women, the safety and efficacy of BLT both in prevention and treatment of PND. Trial registration: ClinicalTrials.gov NCT02664467. Registered 13 January 2016.

Original language	English
Article number	374
Journal	BMC Psychiatry
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12888-016-1086-0
Publication status	Published - 04.11.2016

Funding

This project is supported by: The Swiss National Science Foundation (grant: 320030_160250/1) and The Italian Ministry of Health and Emilia-Romagna Region (grant: PE-2011-02348727). The study protocol has undergone a comprehensive peer-review by the funding bodies in order to obtain financial support from two competitive grants. Lamps for bright light therapy and actigraphy devices are provided for free by Philips Respironics, Italy. FC, AC, NR and MM are PI of the study. FC is recipient of the grant from the Italian Ministry of Health and Emilia-Romagna Region. MM and CC are recipients of the grant from the Swiss National Science Foundation. The other authors have all be involved in developing the study design and drafting the original protocol. They are all included in the respective staff lists of the participating study centers and will be responsible for the development of the project. All authors read and approved the final manuscript.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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Cite this

Baiardi, S., Cirignotta, F., Cicolin, A., Garbazza, C., D'Agostino, A., Gambini, O., Giordano, A., Canevini, M., Zambrelli, E., Marconi, A. M., Mondini, S., Borgwardt, S., Cajochen, C., Rizzo, N., & Manconi, M. (2016). Chronobiology, sleep-related risk factors and light therapy in perinatal depression: The "Life-ON" project. BMC Psychiatry, 16(1), Article 374. https://doi.org/10.1186/s12888-016-1086-0

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abstract = "Background: Perinatal depression (PND) has an overall estimated prevalence of roughly 12 \%. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship. Bright light therapy (BLT) is a well-tested and safe treatment, effective in both depression and circadian/sleep disorders. Methods: In a 3-year longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery. The primary aim of the present study is to systematically explore and characterize risk factors for PND by prospective sleep assessment (using wrist actigraphy, polysomnography and various sleep questionnaires) and bloodbased analysis of potential markers during the perinatal period (Life-ON study). Secondary aims are to explore the relationship between specific genetic polymorphisms and PND (substudy Life-ON1), to investigate the effectiveness of BLT in treating PND (substudy Life-ON2) and to test whether a short term trial of BLT during pregnancy can prevent PND (substudy Life-ON3). Discussion: The characterization of specific predictive and risk factors for PND may substantially contribute to improve preventive medical and social strategies for the affected women. The study results are expected to promote a better understanding of the relationship between sleep disorders and the development of PND and to confirm, in a large sample of women, the safety and efficacy of BLT both in prevention and treatment of PND. Trial registration: ClinicalTrials.gov NCT02664467. Registered 13 January 2016.",

author = "Simone Baiardi and Fabio Cirignotta and Alessandro Cicolin and Corrado Garbazza and Armando D'Agostino and Orsola Gambini and Alessandra Giordano and Mariapaola Canevini and Elena Zambrelli and Marconi, \{Anna Maria\} and Susanna Mondini and Stefan Borgwardt and Christian Cajochen and Nicola Rizzo and Mauro Manconi",

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Baiardi, S, Cirignotta, F, Cicolin, A, Garbazza, C, D'Agostino, A, Gambini, O, Giordano, A, Canevini, M, Zambrelli, E, Marconi, AM, Mondini, S, Borgwardt, S, Cajochen, C, Rizzo, N & Manconi, M 2016, 'Chronobiology, sleep-related risk factors and light therapy in perinatal depression: The "Life-ON" project', BMC Psychiatry, vol. 16, no. 1, 374. https://doi.org/10.1186/s12888-016-1086-0

TY - JOUR

T1 - Chronobiology, sleep-related risk factors and light therapy in perinatal depression

T2 - The "Life-ON" project

AU - Baiardi, Simone

AU - Cirignotta, Fabio

AU - Cicolin, Alessandro

AU - Garbazza, Corrado

AU - D'Agostino, Armando

AU - Gambini, Orsola

AU - Giordano, Alessandra

AU - Canevini, Mariapaola

AU - Zambrelli, Elena

AU - Marconi, Anna Maria

AU - Mondini, Susanna

AU - Borgwardt, Stefan

AU - Cajochen, Christian

AU - Rizzo, Nicola

AU - Manconi, Mauro

PY - 2016/11/4

Y1 - 2016/11/4

N2 - Background: Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship. Bright light therapy (BLT) is a well-tested and safe treatment, effective in both depression and circadian/sleep disorders. Methods: In a 3-year longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery. The primary aim of the present study is to systematically explore and characterize risk factors for PND by prospective sleep assessment (using wrist actigraphy, polysomnography and various sleep questionnaires) and bloodbased analysis of potential markers during the perinatal period (Life-ON study). Secondary aims are to explore the relationship between specific genetic polymorphisms and PND (substudy Life-ON1), to investigate the effectiveness of BLT in treating PND (substudy Life-ON2) and to test whether a short term trial of BLT during pregnancy can prevent PND (substudy Life-ON3). Discussion: The characterization of specific predictive and risk factors for PND may substantially contribute to improve preventive medical and social strategies for the affected women. The study results are expected to promote a better understanding of the relationship between sleep disorders and the development of PND and to confirm, in a large sample of women, the safety and efficacy of BLT both in prevention and treatment of PND. Trial registration: ClinicalTrials.gov NCT02664467. Registered 13 January 2016.

AB - Background: Perinatal depression (PND) has an overall estimated prevalence of roughly 12 %. Untreated PND has significant negative consequences not only on the health of the mothers, but also on the physical, emotional and cognitive development of their children. No certain risk factors are known to predict PND and no completely safe drug treatments are available during pregnancy and breastfeeding. Sleep and depression are strongly related to each other because of a solid reciprocal causal relationship. Bright light therapy (BLT) is a well-tested and safe treatment, effective in both depression and circadian/sleep disorders. Methods: In a 3-year longitudinal, observational, multicentre study, about 500 women will be recruited and followed-up from early pregnancy (10-15 gestational week) until 12 months after delivery. The primary aim of the present study is to systematically explore and characterize risk factors for PND by prospective sleep assessment (using wrist actigraphy, polysomnography and various sleep questionnaires) and bloodbased analysis of potential markers during the perinatal period (Life-ON study). Secondary aims are to explore the relationship between specific genetic polymorphisms and PND (substudy Life-ON1), to investigate the effectiveness of BLT in treating PND (substudy Life-ON2) and to test whether a short term trial of BLT during pregnancy can prevent PND (substudy Life-ON3). Discussion: The characterization of specific predictive and risk factors for PND may substantially contribute to improve preventive medical and social strategies for the affected women. The study results are expected to promote a better understanding of the relationship between sleep disorders and the development of PND and to confirm, in a large sample of women, the safety and efficacy of BLT both in prevention and treatment of PND. Trial registration: ClinicalTrials.gov NCT02664467. Registered 13 January 2016.

UR - https://www.scopus.com/pages/publications/84994234837

U2 - 10.1186/s12888-016-1086-0

DO - 10.1186/s12888-016-1086-0

M3 - Journal articles

C2 - 27814712

AN - SCOPUS:84994234837

SN - 1471-244X

VL - 16

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 374

ER -

Chronobiology, sleep-related risk factors and light therapy in perinatal depression: The "Life-ON" project

Abstract

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UN SDGs

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