TY - JOUR
T1 - Child Maltreatment and Clinical Outcome in Individuals at Ultra-High Risk for Psychosis in the EU-GEI High Risk Study
AU - EU-GEI High Risk Study
AU - Kraan, Tamar C.
AU - Velthorst, Eva
AU - Themmen, Manouk
AU - Valmaggia, Lucia R.
AU - Kempton, Matthew J.
AU - McGuire, Phillip
AU - Van Os, Jim
AU - Rutten, Bart P.F.
AU - Smit, Filip
AU - De Haan, Lieuwe
AU - Van Der Gaag, Mark
AU - Calem, Maria
AU - Tognin, Stefania
AU - Modinos, Gemma
AU - Burger, Nadine
AU - Van Dam, Daniella S.
AU - Barrantes-Vidal, Neus
AU - Domínguez-Martínez, Tecelli
AU - Cristóbal-Narváez, Paula
AU - Kwapil, Thomas R.
AU - Monsonet-Bardají, Manel
AU - Hinojosa, Lídia
AU - Riecher-Rössler, Anita
AU - Borgwardt, Stefan
AU - Rapp, Charlotte
AU - Ittig, Sarah
AU - Studerus, Erich
AU - Smieskova, Renata
AU - Bressan, Rodrigo
AU - Gadelha, Ary
AU - Brietzke, Elisa
AU - Asevedo, Graccielle
AU - Asevedo, Elson
AU - Zugman, Andre
AU - Ruhrmann, Stephan
AU - Gebhard, Dominika
AU - Arnhold, Julia
AU - Klosterkötter, Joachim
AU - Nordholm, Dorte
AU - Randers, Lasse
AU - Krakauer, Kristine
AU - Naumann, Tanya Louise
AU - Glenthøj, Louise Birkedal
AU - Nordentoft, Merete
AU - De Hert, Marc
AU - Van Winkel, Ruud
AU - Nelson, Barnaby
AU - McGorry, Patrick
AU - Amminger, Paul
AU - Pantelis, Christos
N1 - Publisher Copyright:
© The Author(s) 2017.
PY - 2018/4/6
Y1 - 2018/4/6
N2 - Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.
AB - Background: Child maltreatment has been associated with a wide range of mental disorders in adulthood. Whether child maltreatment is specifically associated with psychosis risk in individuals at ultra-high risk (UHR) for psychosis, or leads to a general vulnerability for overall psychopathology in the UHR stage remains unclear. The present study examines the association between child maltreatment and transition to psychosis and other mental disorders. Methods: The sample consisted of 259 UHR individuals from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Participants were followed-up for 2 years to assess clinical outcome. Clinical outcome was assessed at 6 months, 12 months, and 24 months after baseline. Child maltreatment before the age of 17 years was assessed at baseline. Results: Our findings show that a history of emotional abuse was associated with an increased risk for transition to psychosis (OR = 3.78, 95% CI = 1.17 to 12.39, P = -027). Apart from psychosis, a history of physical abuse was associated with depressive disorder (OR = 4.92, 95% CI = 2.12 to 11.39, P = .001), post-traumatic stress disorder (OR = 2.06, 95% CI = 1.10 to 3.86, P = .023), panic disorder (OR = 2.00, 95% CI = 1.00 to 3.99, P = .048) and social phobia (OR = 2.47, 95% CI = 1.18 to 5.16, P = .016) at follow-up. Conclusion: Our findings suggest that in the UHR stage child maltreatment is a pluripotent risk factor for developing psychosis, depressive disorder, post-traumatic stress disorder (PTSD), panic disorder, and social phobia in adulthood.
UR - http://www.scopus.com/inward/record.url?scp=85045141193&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbw162
DO - 10.1093/schbul/sbw162
M3 - Journal articles
C2 - 28666366
AN - SCOPUS:85045141193
SN - 0586-7614
VL - 44
SP - 584
EP - 592
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 3
ER -