Chemical shift assignments of the fibronectin III like domains 7–8 of type VII collagen

Ulrike Hermsdorf, Karsten Seeger

Abstract

Type VII collagen (Col7) is important for skin stability. This is underlined by the severe skin blistering phenotype in the Col7 related diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita (EBA). Col7 has a large N-terminal non-collagenous domain (NC1) that is followed by the triple helical collagenous domain. The NC1 domain has subdomains with homology to adhesion molecules and mediates important interactions within the extracellular matrix. An 185 amino acid long part of the NC1-subdomain termed fibronectin III like domains 7 and 8 (FNIII7-8) was investigated. Antibodies against this region are pathogenic in a mouse model of EBA and one reported missense mutations of Col7 lies within these domains. The nearly complete NMR resonance assignment of recombinant FNIII7-8 of Col7 is reported.
Original languageEnglish
JournalBiomolecular NMR Assignments
Volume10
Issue number1
Pages (from-to)53-55
Number of pages3
ISSN1874-270X
DOIs
Publication statusPublished - 01.04.2016

Fingerprint

Dive into the research topics of 'Chemical shift assignments of the fibronectin III like domains 7–8 of type VII collagen'. Together they form a unique fingerprint.

Cite this