TY - JOUR
T1 - Characterization of synovial macrophages by monoclonal antibodies in rheumatoid arthritis and osteoarthritis
AU - Helbig, B.
AU - Gross, W. L.
AU - Borisch, B.
AU - Starz, H.
AU - Müller-Hermelink, H. K.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - Inflamed synovium in rheumatoid arthritis (RA) and activated (inflammatory) osteoarthritis (aOA) sometimes demonstrates close similarities in routine histology. If the clinical Endings are ambiguous, too, differentiation may become difficult, and the only diagnosis is "chronic unspecific synovitis" By immunohistologic staining with monoclonal antibodies of the Ki-M-series directed against cells of the monocyte/macro-phage lineage semiquantitative evaluation of tissue samples is possible thus gaining helpful results for the differential diagnosis. There are significantly more macrophages in RA than in aOA especially in the synovial lining. Proliferating and activation markers also show slight but significant augmentation (OKT 9) in RA.
AB - Inflamed synovium in rheumatoid arthritis (RA) and activated (inflammatory) osteoarthritis (aOA) sometimes demonstrates close similarities in routine histology. If the clinical Endings are ambiguous, too, differentiation may become difficult, and the only diagnosis is "chronic unspecific synovitis" By immunohistologic staining with monoclonal antibodies of the Ki-M-series directed against cells of the monocyte/macro-phage lineage semiquantitative evaluation of tissue samples is possible thus gaining helpful results for the differential diagnosis. There are significantly more macrophages in RA than in aOA especially in the synovial lining. Proliferating and activation markers also show slight but significant augmentation (OKT 9) in RA.
UR - http://www.scopus.com/inward/record.url?scp=0024154675&partnerID=8YFLogxK
U2 - 10.3109/03009748809102953
DO - 10.3109/03009748809102953
M3 - Journal articles
C2 - 3075089
AN - SCOPUS:0024154675
SN - 0300-9742
VL - 17
SP - 61
EP - 66
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
IS - S76
ER -