Characterization of synovial macrophages by monoclonal antibodies in rheumatoid arthritis and osteoarthritis

B. Helbig*, W. L. Gross, B. Borisch, H. Starz, H. K. Müller-Hermelink

*Corresponding author for this work
7 Citations (Scopus)

Abstract

Inflamed synovium in rheumatoid arthritis (RA) and activated (inflammatory) osteoarthritis (aOA) sometimes demonstrates close similarities in routine histology. If the clinical Endings are ambiguous, too, differentiation may become difficult, and the only diagnosis is "chronic unspecific synovitis" By immunohistologic staining with monoclonal antibodies of the Ki-M-series directed against cells of the monocyte/macro-phage lineage semiquantitative evaluation of tissue samples is possible thus gaining helpful results for the differential diagnosis. There are significantly more macrophages in RA than in aOA especially in the synovial lining. Proliferating and activation markers also show slight but significant augmentation (OKT 9) in RA.

Original languageEnglish
JournalScandinavian Journal of Rheumatology
Volume17
Issue numberS76
Pages (from-to)61-66
Number of pages6
ISSN0300-9742
DOIs
Publication statusPublished - 1988

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

Fingerprint

Dive into the research topics of 'Characterization of synovial macrophages by monoclonal antibodies in rheumatoid arthritis and osteoarthritis'. Together they form a unique fingerprint.

Cite this