TY - JOUR
T1 - Characterization of Micro- and Nanoscale LuPO4: Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy
AU - Espinoza, Sara
AU - Müller, Matthias
AU - Jenneboer, Heike
AU - Peulen, Lukas
AU - Bradley, Tiara
AU - Purschke, Martin
AU - Haase, Markus
AU - Rahmanzadeh, Ramtin
AU - Jüstel, Thomas
PY - 2019/10/1
Y1 - 2019/10/1
N2 - UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.
AB - UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach.
UR - http://www.scopus.com/inward/record.url?scp=85071376784&partnerID=8YFLogxK
U2 - 10.1002/ppsc.201900280
DO - 10.1002/ppsc.201900280
M3 - Journal articles
AN - SCOPUS:85071376784
SN - 0934-0866
VL - 36
JO - Particle and Particle Systems Characterization
JF - Particle and Particle Systems Characterization
IS - 10
M1 - 1900280
ER -
