Central nervous system involvement in adults with epidemic hemolytic uremic syndrome

M. Wengenroth*, J. Hoeltje, J. Repenthin, T. N. Meyer, F. Bonk, H. Becker, S. Faiss, O. Stammel, P. P. Urban, R. Bruening

*Corresponding author for this work
13 Citations (Scopus)


Hemolytic uremic syndrome is a multisystem disorder that is caused by infection with Shiga-toxin-producing Escherichia coli. HUS affects mainly children and is rare among adults. This retrospective case series analyzes clinical signs andMRimaging findings of 11 adult patients with HUS associated nervous system involvement during the epidemic EHEC outbreak in northern Europe with its epicenter in Hamburg in May 2011. The most prevalent imaging finding was symmetric pointy vasogenic edema of the brain stem in the acute and subacute phases of the disease (n = 5). One patient exhibited additional symmetric mesiotemporal signal changes mimicking limbic encephalitis. Two patients developed subcortical patchy lesions, and 4 subjects did not present with any signal changes. Remarkably, territorial ischemia, signs of hemorrhage, or blood-brain barrier disruption have not been detected. While brain stem lesions were transient and normalized with clinical recovery, supratentorial lesions did not resolve completely at 2-month follow-up examination.

Original languageEnglish
JournalAmerican Journal of Neuroradiology
Issue number5
Pages (from-to)1016-1021
Number of pages6
Publication statusPublished - 05.2013


Dive into the research topics of 'Central nervous system involvement in adults with epidemic hemolytic uremic syndrome'. Together they form a unique fingerprint.

Cite this