Abstract
The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. Event-related potentials ·Recognition memory ·Auditory attention ·Central nervous system · Sildenafil & Springer-Verlag 2001.
| Original language | English |
|---|---|
| Journal | World Journal of Urology |
| Volume | 19 |
| Issue number | 1 |
| Pages (from-to) | 46-50 |
| Number of pages | 5 |
| ISSN | 0724-4983 |
| DOIs | |
| Publication status | Published - 01.01.2001 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
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