Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: A study with event-related brain potentials

D. Schultheiss; V. Müller; Wido Nager; C. G. Stief; N. Schlote; U. Jonas; C. Asvestis; Johannes Schurig; Thomas Münte

doi:10.1007/PL00007092

Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: A study with event-related brain potentials

D. Schultheiss^*, V. Müller, Wido Nager, C. G. Stief, N. Schlote, U. Jonas, C. Asvestis, Johannes Schurig, Thomas Münte

^*Corresponding author for this work

Clinic of Neurology

85 Citations (Scopus)

Abstract

The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. Event-related potentials ·Recognition memory ·Auditory attention ·Central nervous system · Sildenafil & Springer-Verlag 2001.

Original language	English
Journal	World Journal of Urology
Volume	19
Issue number	1
Pages (from-to)	46-50
Number of pages	5
ISSN	0724-4983
DOIs	https://doi.org/10.1007/PL00007092
Publication status	Published - 01.01.2001

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: A study with event-related brain potentials",

abstract = "The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. Event-related potentials ·Recognition memory ·Auditory attention ·Central nervous system · Sildenafil & Springer-Verlag 2001.",

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AU - Müller, V.

AU - Nager, Wido

AU - Stief, C. G.

AU - Schlote, N.

AU - Jonas, U.

AU - Asvestis, C.

AU - Schurig, Johannes

AU - Münte, Thomas

PY - 2001/1/1

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N2 - The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. Event-related potentials ·Recognition memory ·Auditory attention ·Central nervous system · Sildenafil & Springer-Verlag 2001.

AB - The purpose of this study was to assess possible central side-effects of sildenafil (Viagra) on attention and memory functions. Sildenafil and placebo were administered in young male subjects in a double-blind balanced cross-over design. Behavioral patterns and event-related brain potentials (ERP) were recorded in a spatial auditory attention and a visual word recognition task. While behavioral patterns did not reveal any overt effects of sildenafil, auditory ERPs were indicative of an enhanced ability to focus attention (amplitude enhancement of Nd-effect) and to select relevant target stimuli in the sildenafil condition (P3 component). In the memory task, CNS-effects of sildenafil were evident in a reduction of a negativity in the 150-250 ms range. No overt effects on behavior were observed. Nevertheless, the data reveal CNS-effects of sildenafil necessitating further studies. Event-related potentials ·Recognition memory ·Auditory attention ·Central nervous system · Sildenafil & Springer-Verlag 2001.

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Central effects of sildenafil (Viagra) on auditory selective attention and verbal recognition memory in humans: A study with event-related brain potentials

Abstract

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