Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Swantje Thiele; Stephanie Stanelle-Bertram; Sebastian Beck; Nancy Mounogou Kouassi; Martin Zickler; Martin Müller; Berfin Tuku; Patricia Resa-Infante; Debby van Riel; Malik Alawi; Thomas Günther; Franziska Rother; Stefanie Hügel; Susanne Reimering; Alice McHardy; Adam Grundhoff; Wolfram Brune; Albert Osterhaus; Michael Bader; Enno Hartmann; Gülsah Gabriel

doi:10.1016/j.celrep.2020.107549

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Swantje Thiele, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Martin Zickler, Martin Müller, Berfin Tuku, Patricia Resa-Infante, Debby van Riel, Malik Alawi, Thomas Günther, Franziska Rother, Stefanie Hügel, Susanne Reimering, Alice McHardy, Adam Grundhoff, Wolfram Brune, Albert Osterhaus, Michael Bader, Enno HartmannGülsah Gabriel^*

^*Corresponding author for this work

Institute of Biology

18 Citations (Scopus)

Abstract

Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.

Original language	English
Article number	107549
Journal	Cell Reports
Volume	31
Issue number	3
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2020.107549
Publication status	Published - 21.04.2020

Funding

The Heinrich Pette Institute, Leibniz Institute for Experimental Virology is supported by the Free and Hanseatic City of Hamburg and the Federal Ministry of Health. P.R.-I. was funded by the Alexander von Humboldt Foundation ( 3.3SPA/1142463 STP-2 ). We thank Peter König (University of Lübeck, Germany) for his support with the laser microbeam microdissection. We thank Hans-Dieter Klenk and Volker Czudai-Matwich (Philipps University of Marburg, Germany) for the human H5N1 and Ron Fouchier (Erasmus Medical Center, Rotterdam, the Netherlands) for the human H7N7 isolates. We thank Adam Grundhoff and Daniela Indenbrinken for the transcriptome analysis. We are grateful to Iris Alpers, Gökhan Arman-Kalcek, Christopher Bergfeld, Kathy Budler, Ilara Hudjetz, Lonneke Leijten, Hanna Markowsky, Annette Preuß, and Nele Twisselmann for excellent technical assistance.

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.107549

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Thiele, S., Stanelle-Bertram, S., Beck, S., Kouassi, N. M., Zickler, M., Müller, M., Tuku, B., Resa-Infante, P., van Riel, D., Alawi, M., Günther, T., Rother, F., Hügel, S., Reimering, S., McHardy, A., Grundhoff, A., Brune, W., Osterhaus, A., Bader, M., ... Gabriel, G. (2020). Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. Cell Reports, 31(3), Article 107549. https://doi.org/10.1016/j.celrep.2020.107549

@article{99cb2f287b8743bf8568cf25157ccdd2,

title = "Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection",

abstract = "Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.",

author = "Swantje Thiele and Stephanie Stanelle-Bertram and Sebastian Beck and Kouassi, \{Nancy Mounogou\} and Martin Zickler and Martin M{\"u}ller and Berfin Tuku and Patricia Resa-Infante and \{van Riel\}, Debby and Malik Alawi and Thomas G{\"u}nther and Franziska Rother and Stefanie H{\"u}gel and Susanne Reimering and Alice McHardy and Adam Grundhoff and Wolfram Brune and Albert Osterhaus and Michael Bader and Enno Hartmann and G{\"u}lsah Gabriel",

note = "Funding Information: The Heinrich Pette Institute, Leibniz Institute for Experimental Virology is supported by the Free and Hanseatic City of Hamburg and the Federal Ministry of Health. P.R.-I. was funded by the Alexander von Humboldt Foundation ( 3.3SPA/1142463 STP-2 ). We thank Peter K{\"o}nig (University of L{\"u}beck, Germany) for his support with the laser microbeam microdissection. We thank Hans-Dieter Klenk and Volker Czudai-Matwich (Philipps University of Marburg, Germany) for the human H5N1 and Ron Fouchier (Erasmus Medical Center, Rotterdam, the Netherlands) for the human H7N7 isolates. We thank Adam Grundhoff and Daniela Indenbrinken for the transcriptome analysis. We are grateful to Iris Alpers, G{\"o}khan Arman-Kalcek, Christopher Bergfeld, Kathy Budler, Ilara Hudjetz, Lonneke Leijten, Hanna Markowsky, Annette Preu{\ss}, and Nele Twisselmann for excellent technical assistance. Publisher Copyright: {\textcopyright} 2020 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

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doi = "10.1016/j.celrep.2020.107549",

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Thiele, S, Stanelle-Bertram, S, Beck, S, Kouassi, NM, Zickler, M, Müller, M, Tuku, B, Resa-Infante, P, van Riel, D, Alawi, M, Günther, T, Rother, F, Hügel, S, Reimering, S, McHardy, A, Grundhoff, A, Brune, W, Osterhaus, A, Bader, M, Hartmann, E & Gabriel, G 2020, 'Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection', Cell Reports, vol. 31, no. 3, 107549. https://doi.org/10.1016/j.celrep.2020.107549

TY - JOUR

T1 - Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

AU - Thiele, Swantje

AU - Stanelle-Bertram, Stephanie

AU - Beck, Sebastian

AU - Kouassi, Nancy Mounogou

AU - Zickler, Martin

AU - Müller, Martin

AU - Tuku, Berfin

AU - Resa-Infante, Patricia

AU - van Riel, Debby

AU - Alawi, Malik

AU - Günther, Thomas

AU - Rother, Franziska

AU - Hügel, Stefanie

AU - Reimering, Susanne

AU - McHardy, Alice

AU - Grundhoff, Adam

AU - Brune, Wolfram

AU - Osterhaus, Albert

AU - Bader, Michael

AU - Hartmann, Enno

AU - Gabriel, Gülsah

N1 - Funding Information: The Heinrich Pette Institute, Leibniz Institute for Experimental Virology is supported by the Free and Hanseatic City of Hamburg and the Federal Ministry of Health. P.R.-I. was funded by the Alexander von Humboldt Foundation ( 3.3SPA/1142463 STP-2 ). We thank Peter König (University of Lübeck, Germany) for his support with the laser microbeam microdissection. We thank Hans-Dieter Klenk and Volker Czudai-Matwich (Philipps University of Marburg, Germany) for the human H5N1 and Ron Fouchier (Erasmus Medical Center, Rotterdam, the Netherlands) for the human H7N7 isolates. We thank Adam Grundhoff and Daniela Indenbrinken for the transcriptome analysis. We are grateful to Iris Alpers, Gökhan Arman-Kalcek, Christopher Bergfeld, Kathy Budler, Ilara Hudjetz, Lonneke Leijten, Hanna Markowsky, Annette Preuß, and Nele Twisselmann for excellent technical assistance. Publisher Copyright: © 2020 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.

AB - Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.

UR - https://www.scopus.com/pages/publications/85083307213

U2 - 10.1016/j.celrep.2020.107549

DO - 10.1016/j.celrep.2020.107549

M3 - Journal articles

C2 - 32320654

AN - SCOPUS:85083307213

SN - 2211-1247

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 107549

ER -

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Abstract

Funding

Research Areas and Centers

UN SDGs

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