Abstract
Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4+ T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose.
| Original language | English |
|---|---|
| Journal | International Journal of Biochemistry and Cell Biology |
| Volume | 45 |
| Issue number | 12 |
| Pages (from-to) | 2808-2820 |
| Number of pages | 13 |
| ISSN | 1357-2725 |
| DOIs | |
| Publication status | Published - 2013 |
Funding
Work in the Kemper laboratory is supported by the MRC Research Grant G1002165 (CK), and the EU-funded Innovative Medicines Initiative BTCURE (CK) . The Dasgupta group is funded by grants from PCUK , The Heathside Trust , EU-FP7 , TUF , GSTT Charity and TSB . The research was also funded by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas’ NHS Foundation Trust and King's College London . The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The authors acknowledge the support of the MRC Centre for Transplantation.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
