CD46: The 'multitasker' of complement proteins

Hidekazu Yamamoto, Antonella Francesca Fara, Prokar Dasgupta, Claudia Kemper*

*Corresponding author for this work
55 Citations (Scopus)


Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4+ T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose.

Original languageEnglish
JournalInternational Journal of Biochemistry and Cell Biology
Issue number12
Pages (from-to)2808-2820
Number of pages13
Publication statusPublished - 2013

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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