CD4 memory T cells on trial: immunological memory without a memory T cell

Eric B. Bell; Jürgen Westermann

doi:10.1016/j.it.2008.06.002

CD4 memory T cells on trial: immunological memory without a memory T cell

Eric B. Bell^*, Jürgen Westermann

^*Corresponding author for this work

Institute of Anatomy

University of Manchester

39 Citations (Scopus)

Abstract

Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

Original language	English
Journal	Trends in Immunology
Volume	29
Issue number	9
Pages (from-to)	405-411
Number of pages	7
ISSN	1471-4906
DOIs	https://doi.org/10.1016/j.it.2008.06.002
Publication status	Published - 09.2008

Funding

This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.it.2008.06.002

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title = "CD4 memory T cells on trial: immunological memory without a memory T cell",

abstract = "Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting na{\"i}ve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.",

author = "Bell, \{Eric B.\} and J{\"u}rgen Westermann",

note = "Funding Information: This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2008",

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AU - Bell, Eric B.

AU - Westermann, Jürgen

N1 - Funding Information: This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008/9

Y1 - 2008/9

N2 - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

AB - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.

UR - https://www.scopus.com/pages/publications/49849105373

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M3 - Journal articles

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SN - 1471-4906

VL - 29

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EP - 411

JO - Trends in Immunology

JF - Trends in Immunology

IS - 9

ER -

CD4 memory T cells on trial: immunological memory without a memory T cell

Abstract

Funding

UN SDGs

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