TY - JOUR
T1 - CD4 memory T cells on trial: immunological memory without a memory T cell
AU - Bell, Eric B.
AU - Westermann, Jürgen
N1 - Funding Information:
This work was supported by TB-VAC of the Sixth Framework Programme of the European Community. We thank David Gray for advice and constructive criticism of the proposal.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.
AB - Immunological memory crucially depends on CD4 T cells. In contrast with B cells, we find no decisive evidence that CD4 T cells are permanently altered by antigen stimulation. We propose that the memory response is derived from an increase in frequency of resting naïve-like CD4 T cells with a half-life of years (or months in rodents), rather than the currently proposed specialized T-cell types that have a known lifespan of days. In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines.
UR - http://www.scopus.com/inward/record.url?scp=49849105373&partnerID=8YFLogxK
U2 - 10.1016/j.it.2008.06.002
DO - 10.1016/j.it.2008.06.002
M3 - Journal articles
C2 - 18674966
AN - SCOPUS:49849105373
SN - 1471-4906
VL - 29
SP - 405
EP - 411
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -
