Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Steffen Desch; Ingo Eitel; Suzanne de Waha; Georg Fuernau; Philipp Lurz; Matthias Gutberlet; Gerhard Schuler; Holger Thiele

doi:10.1186/1745-6215-12-204

Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Steffen Desch^*, Ingo Eitel, Suzanne de Waha, Georg Fuernau, Philipp Lurz, Matthias Gutberlet, Gerhard Schuler, Holger Thiele

^*Corresponding author for this work

University of Leipzig

45 Citations (Scopus)

Abstract

Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented

Original language	English
Article number	204
Journal	Trials
Volume	12
DOIs	https://doi.org/10.1186/1745-6215-12-204
Publication status	Published - 14.09.2011

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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AU - Desch, Steffen

AU - Eitel, Ingo

AU - de Waha, Suzanne

AU - Fuernau, Georg

AU - Lurz, Philipp

AU - Gutberlet, Matthias

AU - Schuler, Gerhard

AU - Thiele, Holger

PY - 2011/9/14

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AB - Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented

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ER -

Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Abstract

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