Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Steffen Desch; Ingo Eitel; Suzanne de Waha; Georg Fuernau; Philipp Lurz; Matthias Gutberlet; Gerhard Schuler; Holger Thiele

doi:10.1186/1745-6215-12-204

Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Steffen Desch^*, Ingo Eitel, Suzanne de Waha, Georg Fuernau, Philipp Lurz, Matthias Gutberlet, Gerhard Schuler, Holger Thiele

^*Corresponding author for this work

University of Leipzig

32 Citations (Scopus)

Abstract

Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented

Original language	English
Article number	204
Journal	Trials
Volume	12
DOIs	https://doi.org/10.1186/1745-6215-12-204
Publication status	Published - 14.09.2011

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1745-6215-12-204

Cite this

@article{def7719a2c0e4fb9a1f4b2ad2ff9cf52,

title = "Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction",

abstract = "Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented",

author = "Steffen Desch and Ingo Eitel and {de Waha}, Suzanne and Georg Fuernau and Philipp Lurz and Matthias Gutberlet and Gerhard Schuler and Holger Thiele",

year = "2011",

month = sep,

day = "14",

doi = "10.1186/1745-6215-12-204",

language = "English",

volume = "12",

journal = "Trials",

}

TY - JOUR

T1 - Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

AU - Desch, Steffen

AU - Eitel, Ingo

AU - de Waha, Suzanne

AU - Fuernau, Georg

AU - Lurz, Philipp

AU - Gutberlet, Matthias

AU - Schuler, Gerhard

AU - Thiele, Holger

PY - 2011/9/14

Y1 - 2011/9/14

N2 - Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented

AB - Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented

UR - http://www.scopus.com/inward/record.url?scp=80052850983&partnerID=8YFLogxK

U2 - 10.1186/1745-6215-12-204

DO - 10.1186/1745-6215-12-204

M3 - Scientific review articles

C2 - 21917147

AN - SCOPUS:80052850983

VL - 12

JO - Trials

JF - Trials

M1 - 204

ER -

Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Abstract

Research Areas and Centers

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this