Cancer immunology and HPV

Barbara Wollenberg

doi:10.1007/978-3-319-43580-0_19

Cancer immunology and HPV

Barbara Wollenberg^*

^*Corresponding author for this work

Department of Otorhinolaryngology, Phoniatrics and Pediatric Audiology

8 Citations (Scopus)

Abstract

HNSCC is a heterogeneous group of tumors located in the oral cavity, oropharynx, hypopharynx and larynx. Originally, tobacco and alcohol exposures were the main risk factors for HNSCC. In the last two decades, HPV infections have been identified as a risk factor for HNSCC, especially for oropharyngeal tumors. Whereas the HPV-induced oropharyngeal carcinomas predominantly express the HPV16 related E6 and E7 oncoproteins, the HPV-negative HNSCC are associated with an overexpression of p53. However, if the therapy successes for HPV-negative and HPV-positive HNSCCs are compared, there are significantly higher total survival rates for HPV-positive oropharyngeal tumors compared to HPV-negative tumors. It is important to understand this phenomenon in order to improve and adapt therapy concepts.

Original language	English
Title of host publication	Recent Results in Cancer Research
Number of pages	6
Publisher	Springer New York LLC
Publication date	01.10.2017
Pages	243-248
ISBN (Print)	978-3-319-43578-7
ISBN (Electronic)	978-3-319-43580-0
DOIs	https://doi.org/10.1007/978-3-319-43580-0_19
Publication status	Published - 01.10.2017

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SDG 3 Good Health and Well-being

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10.1007/978-3-319-43580-0_19

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AB - HNSCC is a heterogeneous group of tumors located in the oral cavity, oropharynx, hypopharynx and larynx. Originally, tobacco and alcohol exposures were the main risk factors for HNSCC. In the last two decades, HPV infections have been identified as a risk factor for HNSCC, especially for oropharyngeal tumors. Whereas the HPV-induced oropharyngeal carcinomas predominantly express the HPV16 related E6 and E7 oncoproteins, the HPV-negative HNSCC are associated with an overexpression of p53. However, if the therapy successes for HPV-negative and HPV-positive HNSCCs are compared, there are significantly higher total survival rates for HPV-positive oropharyngeal tumors compared to HPV-negative tumors. It is important to understand this phenomenon in order to improve and adapt therapy concepts.

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Cancer immunology and HPV

Abstract

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