Cancer immunology and HPV

Barbara Wollenberg*

*Corresponding author for this work
4 Citations (Scopus)


HNSCC is a heterogeneous group of tumors located in the oral cavity, oropharynx, hypopharynx and larynx. Originally, tobacco and alcohol exposures were the main risk factors for HNSCC. In the last two decades, HPV infections have been identified as a risk factor for HNSCC, especially for oropharyngeal tumors. Whereas the HPV-induced oropharyngeal carcinomas predominantly express the HPV16 related E6 and E7 oncoproteins, the HPV-negative HNSCC are associated with an overexpression of p53. However, if the therapy successes for HPV-negative and HPV-positive HNSCCs are compared, there are significantly higher total survival rates for HPV-positive oropharyngeal tumors compared to HPV-negative tumors. It is important to understand this phenomenon in order to improve and adapt therapy concepts.

Original languageEnglish
Title of host publicationRecent Results in Cancer Research
Number of pages6
PublisherSpringer New York LLC
Publication date01.10.2017
ISBN (Print)978-3-319-43578-7
ISBN (Electronic)978-3-319-43580-0
Publication statusPublished - 01.10.2017


Dive into the research topics of 'Cancer immunology and HPV'. Together they form a unique fingerprint.

Cite this