TY - JOUR
T1 - Calcium handling proteins
T2 - Structure, function, and modulation by exercise
AU - Locatelli, Jamille
AU - De Assis, Leonardo V.M.
AU - Isoldi, Mauro C.
N1 - Funding Information:
Acknowledgments Research supported by FAPEMIG-RedeToxifar, CNPq, INCT-FAPEMIG-CNPq, Pronex Project Grant (FAPEMIG/ CNPq), and CAPES. Agradecimento ao Prof. Dr. Paulo Bastista de Carvalho, membro do corpo docente da Notre Dame Catholic University of Baltimore, pela colaborac¸ão ao longo desse trabalho.
PY - 2014/3
Y1 - 2014/3
N2 - Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation-contraction process in the heart among those are sarcoplasmic reticulum Ca2+-ATPase, phospholamban, calsequestrin, sodium-calcium exchanger, L-type calcium's channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.
AB - Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation-contraction process in the heart among those are sarcoplasmic reticulum Ca2+-ATPase, phospholamban, calsequestrin, sodium-calcium exchanger, L-type calcium's channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.
UR - http://www.scopus.com/inward/record.url?scp=84896738235&partnerID=8YFLogxK
U2 - 10.1007/s10741-013-9373-z
DO - 10.1007/s10741-013-9373-z
M3 - Journal articles
C2 - 23436107
AN - SCOPUS:84896738235
SN - 1382-4147
VL - 19
SP - 207
EP - 225
JO - Heart failure reviews
JF - Heart failure reviews
IS - 2
ER -
