Calcium handling proteins: Structure, function, and modulation by exercise

Jamille Locatelli, Leonardo V.M. De Assis, Mauro C. Isoldi*

*Corresponding author for this work
14 Citations (Scopus)


Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation-contraction process in the heart among those are sarcoplasmic reticulum Ca2+-ATPase, phospholamban, calsequestrin, sodium-calcium exchanger, L-type calcium's channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.

Original languageEnglish
JournalHeart failure reviews
Issue number2
Pages (from-to)207-225
Number of pages19
Publication statusPublished - 03.2014

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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