Abstract
The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.
| Original language | English |
|---|---|
| Journal | Regulatory Peptides |
| Volume | 125 |
| Issue number | 1-3 |
| Pages (from-to) | 99-102 |
| Number of pages | 4 |
| ISSN | 0167-0115 |
| DOIs | |
| Publication status | Published - 15.02.2005 |
Funding
This study was supported by a grant of the Deutsche Forschungsgemeinschaft (DFG: RI 423/4-2). The technical assistance of Ines Stölting and Gudrun Vierke is gratefully appreciated.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
