Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Christof Burgdorf; Andreas Dendorfer; Thomas Kurz; Gert Richardt

doi:10.1016/j.regpep.2004.08.002

Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Christof Burgdorf, Andreas Dendorfer, Thomas Kurz, Gert Richardt

Abstract

The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l ^-1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

Original language	English
Journal	Regulatory Peptides
Volume	125
Issue number	1-3
Pages (from-to)	99-102
Number of pages	4
ISSN	0167-0115
DOIs	https://doi.org/10.1016/j.regpep.2004.08.002
Publication status	Published - 15.02.2005

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.regpep.2004.08.002

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title = "Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia",

abstract = "The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.",

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AU - Burgdorf, Christof

AU - Dendorfer, Andreas

AU - Kurz, Thomas

AU - Richardt, Gert

PY - 2005/2/15

Y1 - 2005/2/15

N2 - The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

AB - The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 μmol l -1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.

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JO - Regulatory Peptides

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ER -

Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

Abstract

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