C-reaktives Protein vor radikaler Zystektomie. Präoperative Bestimmung von CRP

Translated title of the contribution: C-reactive protein prior to radical cystectomy. Preoperative determination of CRP

M. W. Kramer, A. Heinisch, G. Wegener, M. Abbas, C. Von Klot, I. Peters, H. Tezval, T. R. Herrmann, M. A. Kuczyk, A. S. Merseburger*

*Corresponding author for this work
5 Citations (Scopus)


Background. Numerous studies have shown a positive correlation between elevated C-reactive protein (CRP) and systemic spread of malignancies. The goal of the current study was to assess the predictive significance of preoperative CRP in patients undergoing radical cystectomy (RC). Material and methods. Preoperative CRP values were measured in 194 patients undergoing RC because of urothelial carcinoma between 1996 and 2005. Elevated CRP level was defined as ≥5 mg/l. Results. Preoperative increased CRP values were detected in 89 (45.9%) patients and these patients were more likely to have advanced tumor stages (pT3-4), positive resection margins and positive lymph nodes. Advanced urinary diversions were more common in patients with normal CRP values. In multivariate analysis, CRP was identified as an independent prognostic indicator for poor cancer-specific survival. Conclusion. The results confirm previous reports that showed a prognostic significance of preoperative CRP elevation.

Translated title of the contributionC-reactive protein prior to radical cystectomy. Preoperative determination of CRP
Original languageGerman
JournalUrologe - Ausgabe A
Issue number2
Pages (from-to)222-227
Number of pages6
Publication statusPublished - 02.2014

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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