Bullous pemphigoid induced by IgG targeting type XVII collagen non-NC16A/NC15A extracellular domains is driven by Fc gamma receptor- and complement-mediated effector mechanisms and is ameliorated by neonatal Fc receptor blockade

Manuela Pigors*, Sabrina Patzelt, Niklas Reichhelm, Jenny Dworschak, Stanislav Khil'chenko, Shirin Emtenani, Katja Bieber, Maxi Hofrichter, Mayumi Kamaguchi, Stephanie Goletz, Gabriele Köhl, Jörg Köhl, Lars Komorowski, Christian Probst, Katrien Vanderheyden, Bianca Balbino, Ralf J. Ludwig, Peter Verheesen, Enno Schmidt

*Corresponding author for this work

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    CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Scheffold, A. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Heine, G. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Peipp, M. (Principal Investigator (PI)), Hammers, M. C. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Nimmerjahn, F. (Principal Investigator (PI)), Hutloff, A. (Principal Investigator (PI)), Ibrahim, S. (Principal Investigator (PI)), Wettschureck, N. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)), Schilf, P. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Bacher, P. (Principal Investigator (PI)), Hoffmann, M. (Principal Investigator (PI)), Busch, H. S. (Principal Investigator (PI)), Höppner, M. (Principal Investigator (PI)), Becker, M. (Principal Investigator (PI)), Holtsche, M. M. (Principal Investigator (PI)), Fähnrich, A. (Principal Investigator (PI)), Szymczak, S. (Principal Investigator (PI)), Murthy, S. (Principal Investigator (PI)) & Lux, A. (Principal Investigator (PI))

    01.01.22 → …

    Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

  • EXC 2167: Precision Medicine in Chronic Inflammation (PMI)

    Schreiber, S. (Speaker, Coordinator), Baines, J. F. (Project Staff), Bosch, T. C. G. (Project Staff), Buyx, A. (Project Staff), Erdmann, J. (Project Staff), Franke, A. (Project Staff), Huber, R. (Project Staff), Klein, C. (Project Staff), Köhl, J. (Project Staff), König, I. R. (Project Staff), Lange, C. (Project Staff), Laudes, M. (Project Staff), Lieb, W. (Project Staff), Ludwig, R. (Project Staff), Nebel, A. (Project Staff), Niemann, S. (Project Staff), Rabe, K. F. (Project Staff), Riemekasten, G. (Project Staff), Rose-John, S. (Project Staff), Rosenstiel, P. C. (Project Staff), Schulenburg, H. (Project Staff), Schwarz, K. (Project Staff), Traulsen, A. (Project Staff), Weidinger, S. (Project Staff) & Zillikens, D. (Project Staff)

    01.01.19 → …

    Project: DFG Projects › DFG Cluster of Excellence

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    CRU 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Ibrahim, S. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ehlers, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), König, P. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Schwaninger, M. (Principal Investigator (PI)), Beek, N. (Principal Investigator (PI)), Erdmann, J. (Principal Investigator (PI)), König, I. R. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)) & Busch, H. S. (Principal Investigator (PI))

    01.04.15 → 31.12.23

    Project: DFG Projects › DFG Joint Research: Research Units/Clinical Research Units