Bullöse Autoimmunkrankheiten bei Kindern

Translated title of the contribution: Bullous autoimmune disorders in children

M. Sárdy*, M. Kasperkiewicz

*Corresponding author for this work
4 Citations (Scopus)


We review the pathogenesis, clinical features, diagnosis, differential diagnosis, and therapy of autoimmune bullous skin diseases of childhood, especially of the most common linear IgA dermatosis. In autoimmune bullous diseases, autoantibodies are formed against different adhesion molecules of the skin. These are not only pathophysiologically relevant, but also serve as basis for diagnosis and follow-up of these diseases. In case an autoimmune bullous disease is suspected, histopathology and immunohistopathology (direct immunofluorescence microscopy) as well as serological tests (indirect immunofluorescence microscopy, ELISA, immunoblot) should be performed. Therapy depends on the diagnosis. In IgA-mediated pathogenesis, dapsone can be successfully used. In IgG-mediated diseases, immunosuppression with corticosteroids and steroid-sparing agents should be initiated, although only local therapy is sufficient to control a self-limiting pemphigus neonatorum. In dermatitis herpetiformis, a life-long gluten-free diet is recommended.

Translated title of the contributionBullous autoimmune disorders in children
Original languageGerman
Issue number6
Pages (from-to)447-457
Number of pages11
Publication statusPublished - 01.06.2013


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