Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade

Constanze Banz; Birte Münchow; Klaus Diedrich

doi:10.1016/j.fertnstert.2009.07.1675

Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade

Constanze Banz^*, Birte Münchow, Klaus Diedrich

^*Corresponding author for this work

Department of Gynecology and Obstetrics

University of Kiel

6 Citations (Scopus)

Abstract

The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.

Original language	English
Journal	Fertility and Sterility
Volume	93
Issue number	4
Pages (from-to)	1349-1352
Number of pages	4
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2009.07.1675
Publication status	Published - 01.03.2010

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10.1016/j.fertnstert.2009.07.1675

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title = "Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade",

abstract = "The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.",

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AU - Banz, Constanze

AU - Münchow, Birte

AU - Diedrich, Klaus

PY - 2010/3/1

Y1 - 2010/3/1

N2 - The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.

AB - The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.

UR - https://www.scopus.com/pages/publications/77049090473

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DO - 10.1016/j.fertnstert.2009.07.1675

M3 - Journal articles

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SN - 0015-0282

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JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade

Abstract

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