TY - JOUR
T1 - Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade
AU - Banz, Constanze
AU - Münchow, Birte
AU - Diedrich, Klaus
PY - 2010/3/1
Y1 - 2010/3/1
N2 - The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.
AB - The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.
UR - http://www.scopus.com/inward/record.url?scp=77049090473&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2009.07.1675
DO - 10.1016/j.fertnstert.2009.07.1675
M3 - Journal articles
C2 - 19782349
AN - SCOPUS:77049090473
SN - 0015-0282
VL - 93
SP - 1349
EP - 1352
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -
