Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts

Angeles Canales; Alvaro Mallagaray; Javier Pérez-Castells; Irene Boos; Carlo Unverzagt; Sadine André; Hans Joachim Gabius; Francisco Javier Cañada; Jesús Jiménez-Barbero

doi:10.1002/anie.201307845

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts

Angeles Canales, Alvaro Mallagaray, Javier Pérez-Castells, Irene Boos, Carlo Unverzagt, Sadine André, Hans Joachim Gabius, Francisco Javier Cañada, Jesús Jiménez-Barbero

Institute of Chemistry and Metabolomics

75 Citations (Scopus)

Abstract

Controlling NMR shifts by lanthanides tagged to a "symmetrical" N-glycan (see picture) reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.

Original language	English
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	51
Pages (from-to)	13789-13793
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201307845
Publication status	Published - 16.12.2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1002/anie.201307845

Cite this

Canales, A., Mallagaray, A., Pérez-Castells, J., Boos, I., Unverzagt, C., André, S., Gabius, H. J., Cañada, F. J., & Jiménez-Barbero, J. (2013). Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts. Angewandte Chemie - International Edition, 52(51), 13789-13793. https://doi.org/10.1002/anie.201307845

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abstract = "Controlling NMR shifts by lanthanides tagged to a {"}symmetrical{"} N-glycan (see picture) reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.",

author = "Angeles Canales and Alvaro Mallagaray and Javier P{\'e}rez-Castells and Irene Boos and Carlo Unverzagt and Sadine Andr{\'e} and Gabius, \{Hans Joachim\} and Ca{\~n}ada, \{Francisco Javier\} and Jes{\'u}s Jim{\'e}nez-Barbero",

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Canales, A, Mallagaray, A, Pérez-Castells, J, Boos, I, Unverzagt, C, André, S, Gabius, HJ, Cañada, FJ & Jiménez-Barbero, J 2013, 'Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts', Angewandte Chemie - International Edition, vol. 52, no. 51, pp. 13789-13793. https://doi.org/10.1002/anie.201307845

TY - JOUR

T1 - Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts

AU - Canales, Angeles

AU - Mallagaray, Alvaro

AU - Pérez-Castells, Javier

AU - Boos, Irene

AU - Unverzagt, Carlo

AU - André, Sadine

AU - Gabius, Hans Joachim

AU - Cañada, Francisco Javier

AU - Jiménez-Barbero, Jesús

PY - 2013/12/16

Y1 - 2013/12/16

N2 - Controlling NMR shifts by lanthanides tagged to a "symmetrical" N-glycan (see picture) reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.

AB - Controlling NMR shifts by lanthanides tagged to a "symmetrical" N-glycan (see picture) reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.

UR - https://www.scopus.com/pages/publications/84890445937

U2 - 10.1002/anie.201307845

DO - 10.1002/anie.201307845

M3 - Journal articles

C2 - 24346952

AN - SCOPUS:84890445937

SN - 1433-7851

VL - 52

SP - 13789

EP - 13793

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 51

ER -

Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts

Abstract

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