Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases

Gianna Huber; Franziska Schuster; Walter Raasch

doi:10.1016/j.phrs.2017.06.016

Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases

Gianna Huber, Franziska Schuster, Walter Raasch^*

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

7 Citations (Scopus)

Abstract

Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of the classic RAS can also be found in the brain but, in contrast to the peripheral RAS, how the endogenous RAS is involved in modulating cardiovascular effects in the brain is not fully understood yet. It is a complex system that may work differently in diverse areas of the brain and is linked to the peripheral system by the circumventricular organs (CVO), which do not have a blood brain barrier (BBB). In this review, we focus on the brain angiotensin peptides, their interactions with each other, and the consequences in the central nervous system (CNS) concerning cardiovascular control. Additionally, we present potential drug targets in the brain RAS for the treatment of hypertension.

Original language	English
Journal	Pharmacological Research
Volume	125
Pages (from-to)	72-90
Number of pages	19
ISSN	1043-6618
DOIs	https://doi.org/10.1016/j.phrs.2017.06.016
Publication status	Published - 01.11.2017

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.phrs.2017.06.016

Cite this

@article{70c8584b5f4343d98c6a2326710e268c,

title = "Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases",

abstract = "Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of the classic RAS can also be found in the brain but, in contrast to the peripheral RAS, how the endogenous RAS is involved in modulating cardiovascular effects in the brain is not fully understood yet. It is a complex system that may work differently in diverse areas of the brain and is linked to the peripheral system by the circumventricular organs (CVO), which do not have a blood brain barrier (BBB). In this review, we focus on the brain angiotensin peptides, their interactions with each other, and the consequences in the central nervous system (CNS) concerning cardiovascular control. Additionally, we present potential drug targets in the brain RAS for the treatment of hypertension.",

author = "Gianna Huber and Franziska Schuster and Walter Raasch",

year = "2017",

month = nov,

day = "1",

doi = "10.1016/j.phrs.2017.06.016",

language = "English",

volume = "125",

pages = "72--90",

journal = "Pharmacological Research",

issn = "1043-6618",

}

TY - JOUR

T1 - Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases

AU - Huber, Gianna

AU - Schuster, Franziska

AU - Raasch, Walter

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of the classic RAS can also be found in the brain but, in contrast to the peripheral RAS, how the endogenous RAS is involved in modulating cardiovascular effects in the brain is not fully understood yet. It is a complex system that may work differently in diverse areas of the brain and is linked to the peripheral system by the circumventricular organs (CVO), which do not have a blood brain barrier (BBB). In this review, we focus on the brain angiotensin peptides, their interactions with each other, and the consequences in the central nervous system (CNS) concerning cardiovascular control. Additionally, we present potential drug targets in the brain RAS for the treatment of hypertension.

AB - Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of the classic RAS can also be found in the brain but, in contrast to the peripheral RAS, how the endogenous RAS is involved in modulating cardiovascular effects in the brain is not fully understood yet. It is a complex system that may work differently in diverse areas of the brain and is linked to the peripheral system by the circumventricular organs (CVO), which do not have a blood brain barrier (BBB). In this review, we focus on the brain angiotensin peptides, their interactions with each other, and the consequences in the central nervous system (CNS) concerning cardiovascular control. Additionally, we present potential drug targets in the brain RAS for the treatment of hypertension.

UR - http://www.scopus.com/inward/record.url?scp=85023593785&partnerID=8YFLogxK

U2 - 10.1016/j.phrs.2017.06.016

DO - 10.1016/j.phrs.2017.06.016

M3 - Scientific review articles

C2 - 28687340

AN - SCOPUS:85023593785

SN - 1043-6618

VL - 125

SP - 72

EP - 90

JO - Pharmacological Research

JF - Pharmacological Research

ER -

Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases

Abstract

Research Areas and Centers

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this