Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

D. E. Dietrich; Y. Zhang; L. Bode; T. F. Münte; U. Hauser; P. Schmorl; C. Richter-Witte; T. Gödecke-Koch; S. Feutl; J. Schramm; H. Ludwig; S. Johannes; H. M. Emrich

doi:10.1038/sj.mp.4001688

Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

D. E. Dietrich^*, Y. Zhang, L. Bode, T. F. Münte, U. Hauser, P. Schmorl, C. Richter-Witte, T. Gödecke-Koch, S. Feutl, J. Schramm, H. Ludwig, S. Johannes, H. M. Emrich

^*Corresponding author for this work

Clinic of Neurology

14 Citations (Scopus)

Abstract

Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

Original language	English
Journal	Molecular Psychiatry
Volume	10
Issue number	6
Number of pages	1
ISSN	1359-4184
DOIs	https://doi.org/10.1038/sj.mp.4001688
Publication status	Published - 01.06.2005

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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Dietrich, D. E., Zhang, Y., Bode, L., Münte, T. F., Hauser, U., Schmorl, P., Richter-Witte, C., Gödecke-Koch, T., Feutl, S., Schramm, J., Ludwig, H., Johannes, S., & Emrich, H. M. (2005). Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder. Molecular Psychiatry, 10(6). https://doi.org/10.1038/sj.mp.4001688

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title = "Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder",

abstract = "Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe{\' }) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.",

author = "Dietrich, \{D. E.\} and Y. Zhang and L. Bode and M{\"u}nte, \{T. F.\} and U. Hauser and P. Schmorl and C. Richter-Witte and T. G{\"o}decke-Koch and S. Feutl and J. Schramm and H. Ludwig and S. Johannes and Emrich, \{H. M.\}",

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Dietrich, DE, Zhang, Y, Bode, L, Münte, TF, Hauser, U, Schmorl, P, Richter-Witte, C, Gödecke-Koch, T, Feutl, S, Schramm, J, Ludwig, H, Johannes, S & Emrich, HM 2005, 'Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder', Molecular Psychiatry, vol. 10, no. 6. https://doi.org/10.1038/sj.mp.4001688

TY - JOUR

T1 - Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

AU - Dietrich, D. E.

AU - Zhang, Y.

AU - Bode, L.

AU - Münte, T. F.

AU - Hauser, U.

AU - Schmorl, P.

AU - Richter-Witte, C.

AU - Gödecke-Koch, T.

AU - Feutl, S.

AU - Schramm, J.

AU - Ludwig, H.

AU - Johannes, S.

AU - Emrich, H. M.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

AB - Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180ms) at this electrode pair showed an overall group difference (F(2,21)1⁄46.98; Po0.005) with post hoc tests (Scheffe ́) indicating differences between group H and controls (Po0.01), group H and group L (Po0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01mA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo- occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

UR - https://www.scopus.com/pages/publications/21244483480

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DO - 10.1038/sj.mp.4001688

M3 - Journal articles

C2 - 15668719

AN - SCOPUS:21244483480

SN - 1359-4184

VL - 10

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 6

ER -

Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder

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