Brain Insulin and Leptin Signaling in Metabolic Control. From Animal Research to Clinical Application

Thomas Scherer; Hendrik Lehnert; Manfred Hallschmid

doi:10.1016/j.ecl.2012.11.002

Brain Insulin and Leptin Signaling in Metabolic Control. From Animal Research to Clinical Application

Thomas Scherer^*, Hendrik Lehnert, Manfred Hallschmid

^*Corresponding author for this work

Department of Internal Medicine I

University of Vienna

10 Citations (Scopus)

Abstract

Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.

Original language	English
Journal	Endocrinology and Metabolism Clinics of North America
Volume	42
Issue number	1
Pages (from-to)	109-125
Number of pages	17
ISSN	0889-8529
DOIs	https://doi.org/10.1016/j.ecl.2012.11.002
Publication status	Published - 01.03.2013

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10.1016/j.ecl.2012.11.002

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abstract = "Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.",

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N2 - Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.

AB - Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.

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Brain Insulin and Leptin Signaling in Metabolic Control. From Animal Research to Clinical Application

Abstract

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