TY - JOUR
T1 - Brain Insulin and Leptin Signaling in Metabolic Control. From Animal Research to Clinical Application
AU - Scherer, Thomas
AU - Lehnert, Hendrik
AU - Hallschmid, Manfred
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.
AB - Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides to the brain by, for example, intranasal administration, are discussed.
UR - http://www.scopus.com/inward/record.url?scp=84873254079&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2012.11.002
DO - 10.1016/j.ecl.2012.11.002
M3 - Scientific review articles
C2 - 23391243
AN - SCOPUS:84873254079
SN - 0889-8529
VL - 42
SP - 109
EP - 125
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 1
ER -
