Bradykinin B2BKR receptor polymorphism and left-ventricular growth response

David Brull, Sukhbir Dhamrait, Saul Myerson, Jeanette Erdmann, Vera Regitz-Zagrosek, Mike World, Dudley Pennell, Steve E. Humphries, Hugh Montgomery*

*Corresponding author for this work
86 Citations (Scopus)


Angiotensin-converting-enzyme (ACE) activity regulates left-ventricular growth. The deletion (D), rather than the insertion (I), ACE gene variant is associated with increased ACE activity and kinin degradation, and the absence (-) rather than the presence (+) of a 9 bp deletion in the gene encoding the bradykinin 2 receptor (B2BKR) is associated with greater gene expression. We determined the ACE and B2BKR genotype of 109 male army recruits, and measured their physiological left-ventricular growth response to a 10-week physical training programme. Mean left-ventricular growth was 15.7 g (SE 3.5) in those with ACE genotype D/D and B2BKR genotype +9/+9, but -1.37 g (4.1) in those with ACE genotype I/I and B2BKR genotype -9/-9 (p=0.003 for trend across genotypes). These results suggest that kinins regulate left-ventricular growth, mediating some of the effects of ACE in this regard.

Original languageEnglish
Issue number9288
Pages (from-to)1155-1156
Number of pages2
Publication statusPublished - 06.10.2001


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