Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations

C. Helmchen; A. Schwekendiek; P. P. Pramstaller; K. Hedrich; C. Klein; H. Rambold

doi:10.1007/s00415-006-0168-1

Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations

C. Helmchen^*, A. Schwekendiek, P. P. Pramstaller, K. Hedrich, C. Klein, H. Rambold

^*Corresponding author for this work

European Academy Bozen

13 Citations (Scopus)

Abstract

We investigated saccades, eyelid blinks, and their interaction in symptomatic (n = 22) and asymptomatic (n = 31) subjects with (n = 19) and without (n = 34) Parkin mutations. Saccadic hypometria was correlated with clinical symptoms of Parkinson's disease, irrespective of mutational status. By contrast, blink amplitude was increased in carriers of Parkin mutations independent of their clinical status. Saccade main sequence and blink effects on saccades were normal. We propose that increased blink amplitude may serve as an endophenotype in carriers of Parkin mutations.

Original language	English
Journal	Journal of Neurology
Volume	253
Issue number	8
Pages (from-to)	1071-1075
Number of pages	5
ISSN	0340-5354
DOIs	https://doi.org/10.1007/s00415-006-0168-1
Publication status	Published - 01.08.2006

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title = "Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations",

abstract = "We investigated saccades, eyelid blinks, and their interaction in symptomatic (n = 22) and asymptomatic (n = 31) subjects with (n = 19) and without (n = 34) Parkin mutations. Saccadic hypometria was correlated with clinical symptoms of Parkinson's disease, irrespective of mutational status. By contrast, blink amplitude was increased in carriers of Parkin mutations independent of their clinical status. Saccade main sequence and blink effects on saccades were normal. We propose that increased blink amplitude may serve as an endophenotype in carriers of Parkin mutations.",

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T1 - Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations

AU - Helmchen, C.

AU - Schwekendiek, A.

AU - Pramstaller, P. P.

AU - Hedrich, K.

AU - Klein, C.

AU - Rambold, H.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - We investigated saccades, eyelid blinks, and their interaction in symptomatic (n = 22) and asymptomatic (n = 31) subjects with (n = 19) and without (n = 34) Parkin mutations. Saccadic hypometria was correlated with clinical symptoms of Parkinson's disease, irrespective of mutational status. By contrast, blink amplitude was increased in carriers of Parkin mutations independent of their clinical status. Saccade main sequence and blink effects on saccades were normal. We propose that increased blink amplitude may serve as an endophenotype in carriers of Parkin mutations.

AB - We investigated saccades, eyelid blinks, and their interaction in symptomatic (n = 22) and asymptomatic (n = 31) subjects with (n = 19) and without (n = 34) Parkin mutations. Saccadic hypometria was correlated with clinical symptoms of Parkinson's disease, irrespective of mutational status. By contrast, blink amplitude was increased in carriers of Parkin mutations independent of their clinical status. Saccade main sequence and blink effects on saccades were normal. We propose that increased blink amplitude may serve as an endophenotype in carriers of Parkin mutations.

UR - https://www.scopus.com/pages/publications/33748955694

U2 - 10.1007/s00415-006-0168-1

DO - 10.1007/s00415-006-0168-1

M3 - Journal articles

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SN - 0340-5354

VL - 253

SP - 1071

EP - 1075

JO - Journal of Neurology

JF - Journal of Neurology

IS - 8

ER -

Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations

Abstract

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