Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations

C. Helmchen*, A. Schwekendiek, P. P. Pramstaller, K. Hedrich, C. Klein, H. Rambold

*Corresponding author for this work
9 Citations (Scopus)

Abstract

We investigated saccades, eyelid blinks, and their interaction in symptomatic (n = 22) and asymptomatic (n = 31) subjects with (n = 19) and without (n = 34) Parkin mutations. Saccadic hypometria was correlated with clinical symptoms of Parkinson's disease, irrespective of mutational status. By contrast, blink amplitude was increased in carriers of Parkin mutations independent of their clinical status. Saccade main sequence and blink effects on saccades were normal. We propose that increased blink amplitude may serve as an endophenotype in carriers of Parkin mutations.

Original languageEnglish
JournalJournal of Neurology
Volume253
Issue number8
Pages (from-to)1071-1075
Number of pages5
ISSN0340-5354
DOIs
Publication statusPublished - 01.08.2006

Fingerprint

Dive into the research topics of 'Blink amplitude but not saccadic hypometria indicates carriers of Parkin mutations'. Together they form a unique fingerprint.

Cite this