Biomarkers for Dementia, Fatigue, and Depression in Parkinson's Disease

Tino Prell*, Otto W. Witte, Julian Grosskreutz

*Corresponding author for this work
12 Citations (Scopus)


Parkinson's disease is a common multisystem neurodegenerative disorder characterized by typical motor and non-motor symptoms. There is an urgent need for biomarkers for assessment of disease severity, complications and prognosis. In addition, biomarkers reporting the underlying pathophysiology assist in understanding the disease and developing neuroprotective therapies. Ultimately, biomarkers could be used to develop a more efficient personalized approach for clinical trials and treatment strategies. With the goal to improve quality of life in Parkinson's disease it is essential to understand and objectively monitor non-motor symptoms. This narrative review provides an overview of recent developments of biomarkers (biofluid samples and imaging) for three common neuropsychological syndromes in Parkinson's disease: dementia, fatigue, and depression.

Original languageEnglish
Article number195
JournalFrontiers in Neurology
Publication statusPublished - 08.03.2019
Externally publishedYes

Research Areas and Centers

  • Centers: Center for Neuromuscular Diseases


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