Beneficial effects of 3,4-diaminopyridine on positioning downbeat nystagmus in a circumscribed uvulo-nodular lesion [6]

Christoph Helmchen*, Stefan Gottschalk, Thurid Sander, Peter Trillenberg, Holger Rambold, Andreas Sprenger

*Corresponding author for this work
17 Citations (Scopus)

Abstract

Sirs: Central positioning downbeat nystagmus (pDBN) presents with transient nystagmus in supine or the head hanging position in the absence of DBN in the head erect position. In contrast to central positional downbeat nystagmus, pDBN requires rapid head posi- tioning manoeuvres to be elicited. The pathomechanism and therapy of central pDBN is not yet known and circumscribed lesions are missing so far [1, 2]. We examined the effect of 3,4-diaminopyridine (DAP) [3, 4] on the oculomotor behavior of a patient with pDBN.
Original languageEnglish
JournalJournal of Neurology
Volume254
Issue number8
Pages (from-to)1126-1128
Number of pages3
ISSN0340-5354
DOIs
Publication statusPublished - 01.08.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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