Behavioral outcome measures to improve experimental stroke research

Mustafa G. Balkaya; Rebecca C. Trueman; Johannes Boltze; Dale Corbett; Jukka Jolkkonen

doi:10.1016/j.bbr.2017.07.039

Behavioral outcome measures to improve experimental stroke research

Mustafa G. Balkaya, Rebecca C. Trueman, Johannes Boltze, Dale Corbett, Jukka Jolkkonen^*

^*Corresponding author for this work

Institute of Medical and Marine Biotechnology

4 Citations (Scopus)

Abstract

Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

Original language	English
Journal	Behavioural Brain Research
Volume	352
Pages (from-to)	161-171
Number of pages	11
ISSN	0166-4328
DOIs	https://doi.org/10.1016/j.bbr.2017.07.039
Publication status	Published - 15.10.2018

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Academic Focus: Biomedical Engineering

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10.1016/j.bbr.2017.07.039

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title = "Behavioral outcome measures to improve experimental stroke research",

abstract = "Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.",

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AU - Balkaya, Mustafa G.

AU - Trueman, Rebecca C.

AU - Boltze, Johannes

AU - Corbett, Dale

AU - Jolkkonen, Jukka

PY - 2018/10/15

Y1 - 2018/10/15

N2 - Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

AB - Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This review describes the tests most commonly used to assess motor and sensorimotor function, cognition and mood in stroke animals. Although it is difficult to predict the direction of future research, it may be possible to prevent false-positive results by selecting an appropriate task or a battery of tasks. It is also expected that the upcoming stroke recovery recommendations and the improved dialogue between academy, industry and healthcare professionals will further promote translational success.

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JO - Behavioural Brain Research

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ER -

Behavioral outcome measures to improve experimental stroke research

Abstract

Research Areas and Centers

UN SDGs

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