Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa; Ellen Kanitz; Winfried Otten; Saleh M. Ibrahim

doi:10.1111/j.1749-6632.2008.03960.x

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa^*, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

Leibniz Institute for Farm Animal Biology

34 Citations (Scopus)

Abstract

We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mt^FVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt ^AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

Original language	English
Title of host publication	Neuroimmunomodulation: From Fundamental Biology to Therapy
Number of pages	8
Publisher	Blackwell Publishing Inc.
Publication date	02.2009
Pages	131-138
ISBN (Print)	9781573317467
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03960.x
Publication status	Published - 02.2009

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1111/j.1749-6632.2008.03960.x

Cite this

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title = "Behavior and stress reactivity in mouse strains with mitochondrial DNA variations",

abstract = "We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.",

author = "Ulrike Gimsa and Ellen Kanitz and Winfried Otten and Ibrahim, \{Saleh M.\}",

year = "2009",

month = feb,

doi = "10.1111/j.1749-6632.2008.03960.x",

language = "English",

isbn = "9781573317467",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

pages = "131--138",

booktitle = "Neuroimmunomodulation: From Fundamental Biology to Therapy",

}

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations. / Gimsa, Ulrike; Kanitz, Ellen; Otten, Winfried et al.
Neuroimmunomodulation: From Fundamental Biology to Therapy. Blackwell Publishing Inc., 2009. p. 131-138 (Annals of the New York Academy of Sciences; Vol. 1153).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

TY - GEN

T1 - Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

AU - Gimsa, Ulrike

AU - Kanitz, Ellen

AU - Otten, Winfried

AU - Ibrahim, Saleh M.

PY - 2009/2

Y1 - 2009/2

N2 - We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

AB - We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

UR - https://www.scopus.com/pages/publications/60349089146

U2 - 10.1111/j.1749-6632.2008.03960.x

DO - 10.1111/j.1749-6632.2008.03960.x

M3 - Conference contribution

C2 - 19236336

AN - SCOPUS:60349089146

SN - 9781573317467

T3 - Annals of the New York Academy of Sciences

SP - 131

EP - 138

BT - Neuroimmunomodulation: From Fundamental Biology to Therapy

PB - Blackwell Publishing Inc.

ER -

Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Abstract

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