Behavior and stress reactivity in mouse strains with mitochondrial DNA variations

Ulrike Gimsa*, Ellen Kanitz, Winfried Otten, Saleh M. Ibrahim

*Corresponding author for this work
25 Citations (Scopus)


We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mtFVB/N mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt AKR/J and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.

Original languageEnglish
Title of host publicationNeuroimmunomodulation: From Fundamental Biology to Therapy
Number of pages8
PublisherBlackwell Publishing Inc.
Publication date02.2009
ISBN (Print)9781573317467
Publication statusPublished - 02.2009

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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