Bedeutung von pra- und perinatalen einflussfaktoren beim surfactant- mangelsyndrom fruhgeborener. Eine logistische regressionsanalyse anhand von 1100 fallen

Translated title of the contribution: Influence of pre- and perinatal risk factors on the incidence and severity of respiratory distress syndrome in premature newborn infants

K. Harms*, E. Herting, M. Kron, M. Schill, H. Schiffmann

*Corresponding author for this work
21 Citations (Scopus)

Abstract

Background: Respiratory distress syndrome (RDS) due to surfactant deficiency remains a cause of considerable mortality in the neonatal period. Methods: In a retrospective study we analysed the records of 1109 premature newborns with a birth weight below 1500 g that were treated on our unit. RDS was assumed if the infants needed mechanical ventilation with oxygen supplementation and the typical radiological signs were present on chest x- ray. Results: No changes in the incidence of RDS were found during the period of observation. Below 29 weeks gestational age 90% of infants suffered from RDS (55% severe RDS grade III or IV). The incidence was 75% (grade III or IV: 32%) for infants born at 29 and 30 weeks, 48% (grade III or IV: 15%) at 31 and 32 weeks and 33% (grade III or IV: 6%) for neonates born at 33 weeks of gestation. Using a logistic regression analysis model the following parameters were found to increase the risk for RDS significantly (p < 0.05): no prenatal steroid treatment, Cesarian section, male gender, APGAR at 5 min < 7, metabolic acidosis (base excess ≤ -6 mval) and rectal temperature <36°C on admission. Following gestosis, insufficiency of the placenta and premature rupture of membranes a decrease in the incidence of RDS was observed. Conclusion: We conclude that although some risk factors for RDS will be difficult to exclude (e.g. maternal disease, gender) the incidence and severity of RDS can be reduced, by measures like maternal antenatal steroid treatment. Perinatal asphyxia (low APGAR values and/or acidosis) and hypothermia should be avoided, as these conditions increase the relative risk for developing RDS.

Translated title of the contributionInfluence of pre- and perinatal risk factors on the incidence and severity of respiratory distress syndrome in premature newborn infants
Original languageGerman
JournalZeitschrift fur Geburtshilfe und Neonatologie
Volume201
Issue number6
Pages (from-to)258-262
Number of pages5
ISSN0948-2393
Publication statusPublished - 1997

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Fingerprint

Dive into the research topics of 'Influence of pre- and perinatal risk factors on the incidence and severity of respiratory distress syndrome in premature newborn infants'. Together they form a unique fingerprint.

Cite this